KADCYLA® (ado-trastuzumab emtansine) for HER2+ Metastatic Breast Cancer

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KADCYLA® (ado-trastuzumab emtansine) for HER2+ Metastatic Breast ...

www.conjuher.com/

Discover KADCYLA® (ado-trastuzumab emtansine), a treatment for HER2-positive metastatic breast cancer. Indication Statement Who is KADCYLA® for? KADCYLA ...

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Context analysis of conjuher.com

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च ओ ञ ज उ (h) ए र . च ओ म

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ק(c) (ο) נ ג׳ (u) ה (e) ר . ק(c) (ο) מ

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ц о н й у х e р . ц о м

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Domain name with Greek letters:

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西哦艾娜杰伊吾艾尺伊艾儿 . 西哦艾马

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c³ o¹⁵ n¹⁴ j¹⁰ u²¹ h⁸ e⁵ r¹⁸ . c³ o¹⁵ m¹³

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C V C C V C V C . C V C

<HEAD> DATA INFORMATION

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utf-8

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width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=no

description:

Discover KADCYLA® (ado-trastuzumab emtansine), a treatment for HER2-positive metastatic breast cancer. Indication Statement Who is KADCYLA® for? KADCYLA is approved to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic breast cancer) after prior treatment with trastuzumab (Herceptin) and a taxane. Prior treatment could have been for the initial treatment of breast cancer or for the treatment of cancer that had spread to other parts of the body. Short Safety (for use in pieces with limited efficacy claims such as invitations, MOA, etc.) Important Safety Information What is the most important safety information I should know about KADCYLA? KADCYLA is not the same medicine as trastuzumab (Herceptin). Liver problems • KADCYLA may cause severe liver problems that can be life-threatening. Symptoms of liver problems may include vomiting, nausea, eating disorder (anorexia), yellowing of the skin (jaundice), stomach pain, dark urine, or itching Heart problems • KADCYLA may cause heart problems, including those without symptoms (such as reduced heart function) and those with symptoms (such as congestive heart failure). Symptoms may include swelling of the ankles or legs, shortness of breath, cough, rapid weight gain of greater than 5 lb in less than 24 hours, dizziness or loss of consciousness, or irregular heartbeat Pregnancy • Receiving KADCYLA during pregnancy can result in the death of an unborn baby and birth defects. Birth control should be used while you receive KADCYLA and for 7 months after your last dose of KADCYLA • If you are exposed to KADCYLA during pregnancy or become pregnant within 7 months of your last dose of KADCYLA, contact your healthcare provider right away; you are also encouraged to enroll in the MotHER Pregnancy Registry by calling 1-800-690-6720 or visiting http://www.motherpregnancyregistry.com/ • You are also encouraged to report exposure to KADCYLA during pregnancy, or if you become pregnant within 7 months of your last dose to Genentech by calling 1-888-835-2555 • If you are a mother who is breastfeeding, you should talk with your doctor about either stopping breastfeeding or stopping KADCYLA Contact your doctor right away if you experience symptoms associated with these side effects. What are the additional possible serious side effects of KADCYLA? Lung problems • KADCYLA may cause lung problems, including inflammation of the lung tissue, which can be life- threatening. Signs of lung problems may include trouble breathing, cough, tiredness, and fluid in the lungs Infusion-related reactions • Symptoms of an infusion-related reaction may include one or more of the following: the skin getting hot or red (flushing), chills, fever, trouble breathing, low blood pressure, wheezing, tightening of the muscles in the chest around the airways, or a fast heartbeat. Your doctor will monitor you for infusion-related reactions Serious bleeding • KADCYLA can cause life-threatening bleeding. Taking KADCYLA with other medications used to thin your blood (antiplatelet) or prevent blood clots (anticoagulation) can increase your risk of bleeding. Your doctor should provide additional monitoring if you are taking one of these other drugs while on KADCYLA. Life-threatening bleeding may also happen with KADCYLA, even when blood thinners are not also being taken Low platelet count • Low platelet count may happen during treatment with KADCYLA. Platelets help your blood to clot. Signs of low platelets may include easy bruising, bleeding, and prolonged bleeding from cuts. In mild cases there may not be any symptoms Nerve damage • Symptoms may include numbness and tingling, burning or sharp pain, sensitivity to touch, lack of coordination, muscle weakness, or loss of muscle function Skin reactions around the infusion site • KADCYLA may leak from the vein or needle and cause reactions such as redness, tenderness, skin irritation, or pain or swelling at the infusion site. If this happens, it is more likely to happen within 24 hours of the infusion How will my doctor know if KADCYLA is right for me? You must have a HER2 test to determine if your cancer is HER2-positive before taking KADCYLA, because benefit has been shown only in patients whose tumors are HER2-positive. What are the most common side effects of KADCYLA? The most common side effects seen in people taking KADCYLA are: • Tiredness • Nausea • Pain that affects the bones, muscles, ligaments, and tendons • Bleeding • Low platelet count • Headache • Liver problems • Constipation • Nosebleeds You are encouraged to report side effects to Genentech and the FDA. You may contact Genentech by calling 1-888-835-2555. You may contact the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

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External links in conjuher.com

https://itunes.apple.com/us/app/4her/id892889450?ls=1&mt=8
http://www.gene.com/download/pdf/kadcyla_prescribing.pdf
http://www.gene.com/privacy-policy
http://www.gene.com/terms-conditions
http://www.motherpregnancyregistry.com/
http://www.fda.gov/medwatch
https://geneapi.gene.com/pdf_merge.php?d=1&f2=http://www.gene.com/download/pdf/kadcyla_prescribing.pdf&f1=http://www.kadcyla.com/sites/kadcyla.com.patient/files/kadcyla-brochure.pdf
http://www.gene.com/gene/index.jsp
http://www.omniture.com

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